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Median follow up was 7 years in the Norwegian trial and between 10 and 12 years in the other trials. The three European trials offered once only flexible sigmoidoscopy, which was supplemented by the offer of an additional faecal occult blood test in the Norwegian trial. In the US trial, a second sigmoidoscopy was offered after 3 5 years.Table 1 Overview of randomised controlled trials on impact of flexible sigmoidoscopy: design aspectsView this table:View popupView inlineParticipation rates in the intervention group ranged from 58.3% in the Italian trial to 86.6% in the US trial.

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